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Viral evolution to escape immune responses of T-cells and B-cells

Viral evolution is driven in part by the need to evade immune responses of the host. Through a process of random mutations and selection pressure by the immune system of the host, viruses can develop novel variants that can escape immune responses of both antibodies and T-cells. We are developing computational immunoinformatic tools to predict which mutations are likely driven by immune pressure, including both T-cell and antibody responses. We have been applying these tools to study the evolution of influenza and SARS-CoV-2. Identification of such mutations may help improve vaccine design to combat rapidly evolving pathogens such as SARS-CoV-2.

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Capturing the immunodominant antibody binding modes to the SARS-CoV-2 spike protein

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 T-cell escape prediction pipeline


Contact us

Hertz Lab
Faculty of Health Sciences
Dept. of Microbiology, Immunology and Genetics
National Institute for Biotechnology in the Negev
Bldg. 41, Room 105
Ben-Gurion University of the Negev,
P.O.B. 653, Be'er-Sheva 84105, Israel
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